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AstraZeneca

Computational Chemistry Industrial Placement Student Review

at AstraZeneca

Placement (10 Months+)

Chemistry

Cambridge

Review Submitted: August 2024

Overall Rating

4.9 /5

The Overall Rating is the average of all the ratings given in each category. We take those individual ratings and combine them into one final score!

4/5 - Overview of Role
5/5 - Skills Development
5/5 - Support and Guidance
5/5 - Company Culture
5/5 - Overall Experience
5/5 - Future Career Prospects

Overview of Role

Please give an overview of your role and what this involves on a day-to-day basis.
I primarily develop new capabilities for the AI team. During the first half of my placement I was doing my Masters thesis, so most of my time was spent doing either a literature review or doing research. Most of my time was spent doing research which consisted of developing Python scripts, meeting with individuals to learn about different techniques, benchmarking, and writing up. I now work on a different research project which, but the type of work is similar.
I also work on a drug project. I sit in meetings to discuss the progress of a given molecule in hit-to-lead, and I can perform computational chemistry experiments (such as simulations) to make new suggestions for the team. I have proposed molecules to the team which were synthesised and tested.
Were you given much responsibility during your placement / internship?
I was given autonomy. My supervisor and manager were very understanding of my need to complete my Masters degree during the placement. My projects I completed were self led, and the current project I am working on I proposed myself.
There have been cases where I was personally responsible for running experiments for the drug discovery team.
At no point have I felt pressured or stressed by my team to do certain work, and if I wanted to perform certain experiments myself I could.
Please rate how meaningful the work you were doing was
4/5

Skills Development

Have you learnt any new skills, or developed your existing skills?
Research skills - How to write a literature review, how to do research to a high standard, appropriately benchmarking and validating methods.
Decision making in industry - the priorities of industry are different than academia. I now have a better understanding of the priorities that exist, and also the importance of clearly conveying your ideas to others.
Computational chemistry and AI - AstraZeneca is well known for their molecular AI team and REINVENT. Being able to work closely with this team and use this tool has given me an in-depth understanding or the role of AI in drug discovery.
How would you rate the training provided during your experience?
5/5
How would you rate your development of industry-specific skills during the experience?
5/5
How would you rate your development of personal / soft skills during the experience?
5/5
Please rate how these skills have helped you in your career development
5/5

Support and Guidance

How much support and guidance did you receive during your placement / internship?
I have weekly meetings with my supervisor and biweekly meetings with my manager. The team is very supportive and everyone is happy to meet to discuss problems at any time.
How would you rate the support and guidance from your line manager?
5/5
How would you rate the support and guidance from the wider team?
5/5

Company Culture

What was the company culture and general atmosphere like?
AstraZeneca has a really great culture and atmosphere. Everyone here loves what they do. It's a very inspiring place to be.
How would you rate the inclusiveness of the culture?
5/5
How would you rate the social opportunities?
5/5
How would you rate the diversity initiatives?
5/5
How would you rate the charity, sustainability and corporate social responsibility (CSR) initiatives?
5/5

Overall Experience

To what extent did you enjoy your placement / internship?
I have absolutely loved my placement. I highly recommend this to anyone interested in AI, computational chemistry, and drug discovery.
Please rate your level of enjoyment on your placement / internship
5/5
Please rate how your experience met your expectations
5/5

Future Career Prospects

Please rate the future employment prospects at AstraZeneca
5/5

Recommendations & Advice

Would you recommend AstraZeneca to a friend?
Yes
What advice would you give to others applying to AstraZeneca
The most important thing is to love what you do. Everyone here is enthusiastic and curious about their science. Having passion for science makes you a strong fit for the company culture.
For computational chemistry specifically it is very easy to do your own projects in your spare time. REINVENT is the AstraZeneca AI tool and is available open source - you can try running this yourself. Additionally there are molecular docking tools that are free to download and play with. Trying these tools is a good way to see whether you would enjoy this placement, but also makes you stand out a bit more on your application.
It is also important to remember this is a drug discovery placement. During my technical interview I was only asked medicinal chemistry questions eg explaining the structure of molecules, functional groups, protein-ligand interactions, conformational effects, and wider pharmacokinetics and pharmacodynamics.
In This Review
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